RESUMO
The European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) is one of the world's leading sources of public biomolecular data. Based at the Wellcome Genome Campus in Hinxton, UK, EMBL-EBI is one of six sites of the European Molecular Biology Laboratory (EMBL), Europe's only intergovernmental life sciences organisation. This overview summarises the latest developments in the services provided by EMBL-EBI data resources to scientific communities globally. These developments aim to ensure EMBL-EBI resources meet the current and future needs of these scientific communities, accelerating the impact of open biological data for all.
Assuntos
Academias e Institutos , Biologia Computacional , Biologia Computacional/organização & administração , Biologia Computacional/tendências , Academias e Institutos/organização & administração , Academias e Institutos/tendências , Bases de Dados de Ácidos Nucleicos , Europa (Continente)Assuntos
Academias e Institutos , Pesquisa Biomédica , Cardiologia , Doenças Cardiovasculares , Academias e Institutos/economia , Academias e Institutos/tendências , Pesquisa Biomédica/economia , Pesquisa Biomédica/tendências , Cardiologia/economia , Cardiologia/tendências , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/fisiopatologia , Doenças Cardiovasculares/terapia , Comportamento Cooperativo , Difusão de Inovações , Previsões , Humanos , Cultura Organizacional , Parcerias Público-Privadas , Apoio à Pesquisa como Assunto , Espanha , Local de TrabalhoRESUMO
Target identification and prioritisation are prominent first steps in modern drug discovery. Traditionally, individual scientists have used their expertise to manually interpret scientific literature and prioritise opportunities. However, increasing publication rates and the wider routine coverage of human genes by omic-scale research make it difficult to maintain meaningful overviews from which to identify promising new trends. Here we propose an automated yet flexible pipeline that identifies trends in the scientific corpus which align with the specific interests of a researcher and facilitate an initial prioritisation of opportunities. Using a procedure based on co-citation networks and machine learning, genes and diseases are first parsed from PubMed articles using a novel named entity recognition system together with publication date and supporting information. Then recurrent neural networks are trained to predict the publication dynamics of all human genes. For a user-defined therapeutic focus, genes generating more publications or citations are identified as high-interest targets. We also used topic detection routines to help understand why a gene is trendy and implement a system to propose the most prominent review articles for a potential target. This TrendyGenes pipeline detects emerging targets and pathways and provides a new way to explore the literature for individual researchers, pharmaceutical companies and funding agencies.
Assuntos
Academias e Institutos/tendências , Biomarcadores/metabolismo , Simulação por Computador , Doença/genética , Descoberta de Drogas/tendências , Terapia de Alvo Molecular , Publicações/tendências , Mineração de Dados , Regulação da Expressão Gênica , Predisposição Genética para Doença , Humanos , Aprendizado de Máquina , Redes Neurais de ComputaçãoRESUMO
The COVID-19 pandemic has caused boundless disruptions to every element of life. It has also brought with it lessons from the past that will likely extend into the future as humans continue to interface with the ever-increasing threats of zoonotic diseases. The pandemic has challenged the profession and the Academy to adjust, modify, and adapt. It has also stretched the bounds of what had previously been thought possible within the realms of medicine. As the Academy begins to reach and crest the apex of the epidemic it should be reminded of the many lessons associated with the pandemic and of the constant need to challenge the paradigm of what is possible.
Assuntos
Academias e Institutos/normas , COVID-19/epidemiologia , Educação em Farmácia/normas , Estudantes de Farmácia , Academias e Institutos/tendências , COVID-19/prevenção & controle , Vacinas contra COVID-19/administração & dosagem , Educação em Farmácia/tendências , HumanosAssuntos
Academias e Institutos/tendências , Saúde Global/tendências , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/terapia , Academias e Institutos/organização & administração , Humanos , Organizações/organização & administração , Organizações/tendências , Acidente Vascular Cerebral/diagnósticoRESUMO
The Coronavirus 2019 (COVID-19) pandemic has deepened gender and racial diversity problems in academia. Mentorship shows women and other under-represented groups where the ladders to success are, and helps them avoid the chutes, a revised leaky pipeline metaphor. Here, we identify tangible strategies that will improve gender equity, including increasing active mentorship by male academics.
Assuntos
Academias e Institutos , Minorias Sexuais e de Gênero , Mulheres , Academias e Institutos/tendências , COVID-19 , Emprego , Feminino , Humanos , Masculino , Mentores , UniversidadesRESUMO
In 2019, an outbreak of Mycoplasma pneumoniae occurred at a military academy in China. The attack rate (10.08%,60/595) was significantly different among the units. High-intensity training and crowded environments to which cadets are exposed are the high risk factors for the outbreak of M. pneumoniae. In-time prevention and control measures effectively controlled the spread of the epidemic.
Assuntos
Militares/estatística & dados numéricos , Mycoplasma pneumoniae/patogenicidade , Pneumonia por Mycoplasma/tratamento farmacológico , Academias e Institutos/organização & administração , Academias e Institutos/estatística & dados numéricos , Academias e Institutos/tendências , China/epidemiologia , Surtos de Doenças/estatística & dados numéricos , Humanos , Mycoplasma pneumoniae/efeitos dos fármacos , Pneumonia por Mycoplasma/epidemiologiaAssuntos
Academias e Institutos , Acesso à Informação/ética , Publicações Periódicas como Assunto/tendências , Mídias Sociais , Academias e Institutos/organização & administração , Academias e Institutos/tendências , Pesquisa Biomédica , Humanos , Disseminação de Informação/ética , Disseminação de Informação/métodos , Competência em Informação , Armazenamento e Recuperação da Informação , Mídias Sociais/ética , Mídias Sociais/organização & administração , Mídias Sociais/tendênciasRESUMO
Objective: To conduct an online survey in order to understand neuropsychology trainees' perspectives during the COVID-19 pandemic and identify pertinent concerns, training gaps, and recommendations.Method: A total of 874 neuropsychology trainees (81% female) completed the 69-item survey. Of the included trainees, 48% were doctoral students, 17% were interns, and 35% were postdoctoral residents (50% of resident respondents were in their first year).Results: The majority of neuropsychology trainees reported some impact of the pandemic on their professional and/or personal life. Overall, the impact did not differ by training level, geographic location, or demographic factors. Trainees' primary professional concerns included uncertainty about the impact of the pandemic on their professional future, loss of clinical hours, and desire for increased and ongoing communication from their leadership. A notable percentage of trainees reported increased personal mental health symptoms (i.e. anxiety/depression; 74%/54%), as well as a number of other personal stressors. Despite the transition to telehealth (mostly interviews/feedback sessions), few trainees have prior training or experience in providing neuropsychological services via phone or video platform. A limited proportion of trainees (approximately 10%) were still seeing patients face-to-face for neuropsychological evaluations during the COVID-19 pandemic as of 14 April 2020.Conclusions: The COVID-19 pandemic is impacting neuropsychological training and the well-being of trainees. This survey highlights the importance of communication with trainees during uncertain times. Based on the survey results, recommendations were developed to assist neuropsychology organizations in developing initiatives to support trainees during the current pandemic and in the future.
Assuntos
Academias e Institutos , Betacoronavirus , Infecções por Coronavirus/psicologia , Neuropsicologia/educação , Pneumonia Viral/psicologia , Estudantes de Ciências da Saúde/psicologia , Inquéritos e Questionários , Academias e Institutos/tendências , Adulto , Comitês Consultivos/tendências , COVID-19 , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Feminino , Humanos , Internato não Médico/tendências , Masculino , Transtornos Mentais/epidemiologia , Transtornos Mentais/psicologia , Transtornos Mentais/terapia , Testes Neuropsicológicos , Neuropsicologia/tendências , Pandemias , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , SARS-CoV-2 , Estados Unidos/epidemiologiaAssuntos
Academias e Institutos/tendências , Betacoronavirus , Infecções por Coronavirus/epidemiologia , Oftalmologia/organização & administração , Pneumonia Viral/epidemiologia , COVID-19 , Congressos como Assunto , Educação Continuada em Enfermagem , Política de Saúde , Humanos , Internato e Residência , Oftalmologia/educação , Pandemias , SARS-CoV-2 , Estados UnidosRESUMO
OBJECTIVE: In the present study, we updated our previously reported case series of patients who had undergone decompressive craniectomy for malignant middle cerebral artery infarction (mMCAI) (2005-2020). To the best of our knowledge, the present case series constitutes the largest reported series from a UK neurosurgical unit of decompressive craniectomy for mMCAI. METHODS: We extracted data regarding the clinical discriminators, surgical timescales, and functional outcomes of patients. RESULTS: A total of 67 patients had undergone decompressive craniectomy. The 30-day mortality was 17.9% (n = 12). Of the 67 patients, 31 were male (46.3%) and 36 were female (53.7%). Their mean age was 45 years (range, 16-64 years). The mean age of the survivors was 43 years (range, 16-62 years) compared with 50 years (range, 38-64 years) for those who had died. The median ictal and preoperative Glasgow coma scale score was 14 (range, 7-15) and 8 (range, 3-15), respectively. The corresponding motor scores were 6 and 5. The mean interval from ictus to neurosurgical unit admission was 18.25 hours (range, 0.5-66 hours) and from admission to decompressive craniotomy was 7.30 hours (range, 0.5-46 hours). Of the 67 patients, 63% had undergone "early" craniectomy (<48 hours from mMCAI evolution), with 89% of these patients having undergone craniectomy <24 hours after neurosurgical unit admission. The mean maximum anteroposterior craniectomy diameter was 13.01 cm (range, 10.29-15.56 cm), and mean surface area was 94.38 cm2 (range, 74.75-132.32 cm2). Overall, 46% of patients had had a modified Rankin scale score of <3 (range, 0-6) from discharge to 12 months postoperatively. The median neurosurgical unit length of stay was 15 days (range, 6 hours to 365 days). CONCLUSIONS: The findings from the present update have confirmed that local practice has remained consistent with current evidence. However, patient selection might be optimized if diffusion-weighted magnetic resonance imaging and computed tomography perfusion were used at the original middle cerebral artery infarct admission.
Assuntos
Academias e Institutos/tendências , Craniectomia Descompressiva/tendências , Infarto da Artéria Cerebral Média/epidemiologia , Infarto da Artéria Cerebral Média/cirurgia , Adolescente , Adulto , Feminino , Humanos , Infarto da Artéria Cerebral Média/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Mortalidade/tendências , Estudos Retrospectivos , Escócia/epidemiologia , Fatores de Tempo , Resultado do Tratamento , Adulto JovemAssuntos
Esclerose Amiotrófica Lateral/patologia , Pessoal de Laboratório , Modelos Teóricos , Neurobiologia , Pesquisa com Células-Tronco/história , Células-Tronco/citologia , Academias e Institutos/história , Academias e Institutos/tendências , Esclerose Amiotrófica Lateral/história , Distinções e Prêmios , Pesquisa Biomédica/história , Pesquisa Biomédica/métodos , Pesquisa Biomédica/tendências , História do Século XX , História do Século XXI , Humanos , Pessoal de Laboratório/história , Londres , Neurobiologia/história , Neurobiologia/tendências , Neurologia/história , Neurologia/tendências , Médicos/históriaAssuntos
Academias e Institutos/tendências , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/prevenção & controle , Surtos de Doenças , Técnicas de Diagnóstico Molecular/estatística & dados numéricos , Pneumonia Viral/diagnóstico , Pneumonia Viral/prevenção & controle , Academias e Institutos/economia , COVID-19 , Infecções por Coronavirus/epidemiologia , Genoma Viral/genética , Humanos , Técnicas de Diagnóstico Molecular/economia , Técnicas de Diagnóstico Molecular/tendências , Pneumonia Viral/epidemiologia , Estados Unidos/epidemiologiaAssuntos
Academias e Institutos/organização & administração , Dermatologistas/tendências , Dermatologia/organização & administração , Docentes de Medicina/tendências , Médicas/tendências , Academias e Institutos/história , Academias e Institutos/estatística & dados numéricos , Academias e Institutos/tendências , Estudos Transversais , Dermatologistas/psicologia , Dermatologistas/estatística & dados numéricos , Dermatologia/história , Dermatologia/estatística & dados numéricos , Dermatologia/tendências , Docentes de Medicina/psicologia , Docentes de Medicina/estatística & dados numéricos , História do Século XX , História do Século XXI , Humanos , Liderança , Médicas/psicologia , Médicas/estatística & dados numéricos , Estados UnidosRESUMO
Discovery and development of new medicines requires the talent and passion of both academic and industrial scientists. Identifying the optimal set of circumstances for direct collaboration between academic and industry teams requires a mutual understanding of what each partner brings to the relationship, and an appreciation of the specialized capabilities and scope of work to be undertaken by each group. We provide our perspective on the who, what, where, why, and how for establishing therapeutic and translational research collaborations between academic and industry scientists.